20:00-22:00 Late Session
20:00-20:15 Welcome and Orientation
Hülya Karataş, Müge Yemişçi Özkan
20:15-22:00 Introduction to Spreading Depolarizations: Consensus and Controversies
with Audience Participation
Jed Hartings , Cenk Ayata
08:30-09:30 Keynote
Moderator: Muge Yemisci
  Re-Evaluation of the Role of CSD in Migraine Headache
Hayrunnisa Bolay
09:30-09:40 Coffee Break
09:40-12:05 Oral Presentations
Chair: David Chung, Lydia Hawley
  Initial Results of The Indict Feasibility Trial of Spreading Depolarization Monitoring to Guide Management of Severe Traumatic Brain Injury
Jed Hartings
  Continuous Monitoring of Cerebrovascular Autoregulation Using Functional Ultrasound İmaging in The Piglet Brain
Alan Urban
  Spatial Dynamics of Human Spreading Depolarizations: Preliminary Results Applying a Newly Developed Two-Dimensional Strip
Liangchen Guo
  Cortical Spreading Depolarization During Surgical Management of Cerebral Arteriovenous Malformations and Arteriovenous Fistulas
Patrick Dömer
10:45-11:00 Coffee Break
  Spreading Depolarization Continuum in The Aged Non-Human Primate After Focal Ischemic Stroke
Sergei Kirov
  High-Frequency Oscillations During Cortical Spreading Depolarization
Azat Nasretdinov
  Noninvasive Optical Detection of Spreading Depolarization in Rat
Elyssa Alber
  The Introduction of a Novel Visualization Method of Cerebral Blood Flow Changes in Mice With an Rgb Camera: The Effects of Bosentan on Spreading Depolarizations Induced by Experimental Air-Emboli Model Via External Carotid Artery Cannulation
Ergin Dileköz
12:05-13:00 Lunch Break
13:00-14:35 Oral Presentations
Chair: Jens Dreier, Melike Sever Bahçekapılı
  Mems-Based Su-8 Neural Probes for Enhanced Neuromonitoring
Hasan Uluşan
  Noninvasive, Automated Detection of Spreading Depolarizations Using Scalp Electroencephalography: A Multicenter Validation in Patients With and Without Skull Defect
Alireza Chamanzar
  Standardising Direct Cortical Response Monitoring of Spreading Depolarisations: A Matlab-Based Approach For Automating Optimal Stimulation Channel Selection
Khevna Vasani
  Noninvasive Vs. Invasive Detection of Cortical Spreading Depolarization Via Dc-Shift Comparison
Stephen Jones
  Step Response of Metallic Electrodes
Kevan Hashemi
  Monitoring High-Resolution Electrophysiological Activity of Brain Slices With A Multi-Functional High-Density Microelectrode Array
Hasan Ulusan
14:35-16:30 Posters with Coffee+Snacks
  Detection of Spreading Depolarization-Associated Blood-Brain Barrier Disruption Using Dynamic Contrast-Enhanced MRI
Magnus Kreiberg
  Impairment Of Na+-K+-Atpase in The Human Cortex Under Halogenated Ether Anesthetics is Associated with Disrupted Ion Homeostasis
Mathilde Maechler
  Electrophysiological Characterization of The Pericyte-Endothelial Cell Syncytium in Human Brain Slices From Patients with Pharmacoresistant Mesial Temporal Lobe Epilepsy
Mirja grote Lambers
  Case Report: A Patient With Hemiplegic Migraine And Unilateral Transient Cerebral Hyperperfusion
Yasemin Gürsoy Özdemir
  Protocol Overview: Inhibiting The Nmdar/Trpm4 Interaction as a Neuroprotective Strategy in a Gyrencephalic Brain Model of Ischemic Stroke Through Modulation of Spreading Depolarization
Juan Manuel Lopez Navarro
  A Mems-Based Thin Film Microelectrode Array For Monitoring of Traumatic Brain Injury
Hasan Uluşan
  Alzheimer-Stroke Continuum: The Role Of Spreading Depolarization
Anna Törteli
  Cognitive Impairment and Platelet Dynamics in Mild Traumatic Brain Injury: Insights from a North Indian Cohort
Arulselvi Subramaniam
16:30-17:30 Keynote
Moderator: Cenk Ayata
  Capillaries as Multi-Modal Sensors of Brain Activity
Mark T. Nelson
20:00-21:00 Late Night Roundtable
  SD and Migraine
KC Brennan, Müge Yemişçi Özkan, Elif Akaydın
  Is SD Good or Bad?
Cenk Ayata, Kadir Oğuzhan Soylu
08:30-10:05 Oral Presentations
Chair : Bill Shuttleworth, Else Tolner
  The Impact of Cortical Spreading Depolarization on The Autonomous Nervous System in Critically Brain Injured Patients
Gwendan Percevault
  Impact of Sd İnitiation Site on Outcome of Transient Focal Ischemia
Michael Bennett
  Repetitive Cortical Spreading Depolarizations Exacerbate Tissue Damage and Neurological Deficits Following Traumatic Brain Injury
Faith Best
  Every Cloud Has a Silver Lining: Spreading Depolarization Induction of Neuroprotective Pathways Through Gene Expression Changes.
Michela DellOrco
  Correlation of BDNF Levels with Concussion Symptoms and Neurobehavior Deficits Associated with a Mild Traumatic Brain Injury
Venencia Albert
  Migrainous Infarction: Myth or Reality? A Systematic Review
Emilie Schou
10:05-10:15 Coffee Break
10:15-12:00 Oral Presentations
Chair: KC Brennan, Annika Köhne
  A Novel Model of In Vitro Cortical Spreading Depolarization
Yasemin Gürsoy Özdemir
  Olfactory Bulb Induction of Cortical Spreading Depolarization
Muhammed Miran Oncel
  Effect of Long-Term Optogenetic Stimulation on Electrophysiological Spreading Depolarization Parameters in Mice
Annika Köhne
  Loss of Arousal Following Induction of Cortical Spreading Depolarisation in Awake Mice
Kağan Ağan
  Spontaneous Spreading Depolarizations in Atp1a2 And Atp1a3 Mutant Mice
Else Tolner
  Acute Levcromakalim Injection Induces Migraine-Like Phenotype Without Cortical Spreading Depolarization in Male Wistar Rats
Elif AKAYDIN
  Palytoxin Evokes Reversible Spreading Depolarization in The Locust CNS
R. David Andrew
12:00-13:00 Lunch Break
TBA The Antalya Museum (Antalya Archeological Museum) and Antalya Tour
20:00-21:00 Late Night Roundtables
Clinical SD recordings
Moderators: Martin Fabricius, Beyza Türken
08:30-09:30 Keynote
Moderator: Hulya Karatas
  Spreading Depolarization in the Waking Brain: Insights from Animal Models
Lyudmila Vinogradova
09:30-09:40 Coffee Break
09:40-11:50 Oral Presentations
Chair: Yasemin Gürsoy Özdemir, Johannes Woitzik
  The Slope of The Spreading Depolarization Related Blood Flow Transients is a Potential Biomarker for Risk Stratification in Experimental Ischemic Stroke
Lückl Janos
  Prophylactic Treatment of Migraine With (100%) Aura: Evaluating The Efficacy of Lamotrigine in Preclinical and Clinical Settings
Buket Nebiye Demir
  Impact of Nimodipine on Hemodynamic Fluctuations and Connectivity Dynamics Following Cortical Spreading Depolarizations in a Gyrencephalic Swine Model
Diego Alberto Sandoval Lopez
  Inhibition of Nitric Oxide Synthase Transforms Carotid Occlusion-Mediated Benign Oligemia into Large Cerebral İnfarction
Dong-Eog Kim
10:30-10:45 Coffee Break
  Hyperosmotic Treatment for Neuroprotection: In Vitro Effects of Mannitol
Rita Frank
  Effect of Sın-1 on The Sd-Initiated Nup and The No-Reflow Phenomenon During Forebrain Ischemia and Reperfusion in Rats
Lemale Coline
  Investigating the Effects of Nanoencapsulated Ketamine on Cerebral Blood Flow Responses Post Focal Cortical Ischemia Using Functional Ultrasound Imaging
Lorena Figueiredo Fernandes
  Blood-Brain Barrier Dysfunction in Abnormal Brain Predicts Epilepsy After Subarachnoid Hemorrhage
Dreier Jens
11:50-12:55 Lunch Break
12:55-14:30 Oral Presentations
Chair: Eszther Farkas, Muhammed Miran Öncel
  The Role of an Innate Immune System Pathway in Cortical Spreading Depolarization and Nociception
Kadir Oguzhan Soylu
  Does Spreading Depression Rewire Cortical Pain Networks?
Bengisu Solgun
  Cortical Spreading Depolarization-Induced Nlrp3 Inflammasome Activation Via P2x7 Receptor Activity in Trigeminal Ganglia
Beyza Türken
  How Spreading Depolarizations Shape Epileptic Activity
Roustem Khazipov
  Natural History of Seizures, Spreading Depolarizations And Seizure-Associated Spreading Depolarization in Mouse Models of Epilepsy.
Rob Wykes
  Seizure Propagation Triggers a Protective Contralesional Spreading Depolarization During Focal Hippocampal Stroke in Freely Behaving Female Mice
Andrew Boyce
  Characterization of Spreading Depolarization And Epileptiform Activity Following İnduction of Focal Cerebral Ischemia in Awake Mice.
Samuel Flaherty
14:30-16:30 Posters with Coffee+Snacks
  The Effect of Noninvasive Cortical Spreading Depolarizations on a Test of Executive Function
Lydia Hawley
  Nimodipine Reduces Microglial Activation by Spreading Depolarization and in Response To Lipopolysaccharide, As Evidenced by Morphological Phenotype and RNA Sequencing
István Pesti
  Pre-Stroke or Post-Stroke Spreading Depolarization and Ischemia Do Not Affect Stroke Outcomes in a New Mouse Model of Focal Ischemic Stroke, Naim
Kyusun Han
  Effects of Metabolic Inhibition on Intracellular CA2+ And ATP in Human Cortical Brain Organoid Slice Cultures (CBOS)
Laura Petersilie
  Activation of TRPV4 Channels Promotes The Loss Of Cellular Atp in Mouse Neocortex Exposed to Chemical Ischemia
Nils Pape
  Combined Dasatinib and Quercetin Treatment After Carotid Artery Stenosis Limits Spreading Depolarization During Subsequent Acute Ischemic Stroke in Aging Rats
Szilvia Kecskés
  Pro-Epileptic Effects of Spreading Depolarizations
Daria Vinokurova
  Impact of Cortical Spreading Depolarization on Neural Precursor Dynamics and Neurogenesis in The Adult Dentate Gyrus
Anja Urbach
16:30-17:30 Keynote
Moderator: Jed Hartings
  Clinical Neuromonitoring in the Intensive Care Unit: Spreading Depolarizations in Real Time and in the Real World
Brandon Foreman
20:00-21:00 Late Night Roundtable
  The Potential of Pharmacological Interventions Targeting CSD Pathways
Hülya Karataş, Istvan Pesti
  Carreer Discussions for SD Researchers: Grantsmanship and Promotion
Jed Hartings, Melike Sever Bahçekapılı
09:00-09:30 Recap iCSD 2024
Britta Lindquist
09:30-09:45 Oral and Poster Presentation Awards
09:45-10:00 Concluding Remarks